Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 13/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 5/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1570261 | 0.93 | MAPKAPK5 (0.70) | MAPKAPK5FYNTTKAURKA | |
| SCHEMBL3817462 | 0.86 | MAPKAPK5 (0.54) | MAPKAPK5FYNTTKAURKA | |
| SCHEMBL4297215 | 0.86 | MAPKAPK5 (0.45) | MAPKAPK5FYNTTK | |
| SCHEMBL1570184 | 0.81 | MAPKAPK5 (0.66) | MAPKAPK5FYNTTKAURKA | |
| SCHEMBL1674248 | 0.80 | MAPKAPK5 (0.80) | MAPKAPK5FYNTTKAURKA | |
| SCHEMBL1570335 | 0.79 | MAPKAPK5 (0.64) | MAPKAPK5FYNTTKAURKA | |
| SCHEMBL1570149 | 0.79 | MAPKAPK5 (0.53) | MAPKAPK5TTK | |
| SCHEMBL2389877 | 0.76 | MAPKAPK5 (0.64) | MAPKAPK5FYNTTKAURKA | |
| SCHEMBL10169148 | 0.75 | MAPKAPK5 (0.87) | MAPKAPK5FYNTTKAURKA | |
| SCHEMBL2068760 | 0.75 | MAPKAPK5 (1.00) | MAPKAPK5FYNAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135885-A1 | FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-11-12 | — | — | WO | disclosed |