Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 16/20 | 0.65 |
| ▸ | HCAR3 | P49019 | 11/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3111220 | 0.79 | HCAR2 (1.00) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL11294532 | 0.79 | HCAR2 (0.60) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3820468 | 0.78 | HCAR2 (0.65) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3823505 | 0.77 | HCAR2 (0.66) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3819252 | 0.77 | HCAR2 (0.66) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3819503 | 0.77 | HCAR2 (0.66) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3818988 | 0.76 | HCAR2 (0.65) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3105879 | 0.76 | HCAR2 (0.73) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3823868 | 0.74 | HCAR2 (0.64) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3823775 | 0.73 | HCAR2 (0.65) | HCAR2HCAR3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701947-B1 | 4-OXO-4,5-DIHYDRO-FURAN-2-CARBOXYLIC AND ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARM INC (US) | 2009-08-26 | — | — | EP | claimed |