Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 17/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | ITK | Q08881 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2067665 | 0.89 | NTRK1 (0.54) | NTRK1KDRITK | |
| SCHEMBL2065465 | 0.82 | NTRK1 (0.55) | NTRK1KDRITK | |
| SCHEMBL2065674 | 0.81 | NTRK1 (0.54) | NTRK1KDRITK | |
| SCHEMBL3827871 | 0.79 | NTRK1 (0.38) | NTRK1KDRITK | |
| SCHEMBL2065902 | 0.79 | NTRK1 (0.53) | NTRK1KDRITK | |
| SCHEMBL2065278 | 0.78 | NTRK1 (0.37) | NTRK1KDRITK | |
| SCHEMBL2065104 | 0.77 | NTRK1 (0.56) | NTRK1KDRITK | |
| SCHEMBL2066215 | 0.77 | NTRK1 (0.35) | NTRK1KDRITK | |
| SCHEMBL2066846 | 0.77 | NTRK1 (0.37) | NTRK1KDR | |
| SCHEMBL2065722 | 0.77 | NTRK1 (0.38) | NTRK1KDRITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099794-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008079873-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-03 | — | — | WO | disclosed |