Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine Phosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 known ✓ | P30542 | 3/20 | 0.92 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.77 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.77 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.77 |
| ▸ | P2RY1 | P47900 | 5/20 | 0.92 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.92 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.92 |
| ▸ | SRC | P12931 | 2/20 | 0.92 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.92 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.92 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.92 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.92 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.92 |
| ▸ | LDHA | P00338 | 1/20 | 0.92 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.92 |
| ▸ | FBP1 | P09467 | 1/20 | 0.92 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.92 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.92 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.92 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vidarabine Phosphate SCHEMBL7111227 | 0.99 | P2RY1 (0.90) | P2RY1P2RY2SMN1; SMN2ADORA1SRC | |
| Adenosine Phosphate SCHEMBL290977 | 0.99 | P2RY1 (0.90) | P2RY1P2RY2SMN1; SMN2ADORA1SRC | |
| Adenosine Phosphate SCHEMBL144997 | 0.96 | P2RY1 (1.00) | P2RY1P2RY2SMN1; SMN2ADORA1SRC | |
| Adenosine Phosphate SCHEMBL8572634 | 0.96 | P2RY1 (1.00) | P2RY1P2RY2SMN1; SMN2ADORA1SRC | |
| Adenosine Phosphate SCHEMBL20277555 | 0.96 | P2RY1 (1.00) | P2RY1P2RY2SMN1; SMN2ADORA1SRC | |
| Adenosine Phosphate SCHEMBL1338615 | 0.96 | P2RY1 (1.00) | P2RY1P2RY2SMN1; SMN2ADORA1SRC | |
| Adenosine Phosphate SCHEMBL132458 | 0.96 | P2RY1 (1.00) | P2RY1P2RY2SMN1; SMN2ADORA1SRC | |
| Adenosine Phosphate SCHEMBL19420134 | 0.96 | P2RY1 (1.00) | P2RY1P2RY2SMN1; SMN2ADORA1SRC | |
| Adenosine Phosphate SCHEMBL13170051 | 0.96 | P2RY1 (1.00) | P2RY1P2RY2SMN1; SMN2ADORA1SRC | |
| Adenosine Phosphate SCHEMBL11977309 | 0.96 | P2RY1 (1.00) | P2RY1P2RY2SMN1; SMN2ADORA1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023249425-A1 | FUSION PROTEIN COMPRISING ANTI-CD73 ANTIBODY AND IL-2, AND USE THEREOF | ㈜지아이이노베이션 | 2023-12-28 | — | — | WO | disclosed |
| CN-112779260-B | Aptamer of flavin mononucleotide, screening method and application thereof | 中国科学院苏州纳米技术与纳米仿生研究所 | 2022-08-26 | — | — | CN | disclosed |
| US-20210393856-A1 | COMPOSITIONS AND METHODS FOR REDUCING CALCIFICATION OF HEART VALVES | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2021-12-23 | — | — | US | disclosed |
| CN-113423418-A | Treatment of cilia disease | 埃泽瑞斯公司 | 2021-09-21 | — | — | CN | disclosed |
| CN-112779260-A | Aptamer of flavin mononucleotide, screening method and application thereof | 中国科学院苏州纳米技术与纳米仿生研究所 | 2021-05-11 | — | — | CN | disclosed |
| CN-111671007-A | Pomegranate seeds as feed additive for improving pork quality and flavor and application thereof | 浙江省农业科学院 | 2020-09-18 | — | — | CN | disclosed |
| EP-3701051-A1 | SELECTION AND USE OF MELATONIN SUPPORTING BACTERIA TO REDUCE INFANTILE COLIC | Biogaia AB (SE) | 2020-09-02 | — | — | EP | disclosed |
| CN-111378705-A | Method for preparing adenine and D-ribose by hydrolyzing adenosine with adenosine hydrolase | 通辽德胜生物科技有限公司 | 2020-07-07 | — | — | CN | disclosed |
| CN-111362945-A | Method for synthesizing adenine by adenosine hydrolysis method | 洛阳德胜生物科技股份有限公司 | 2020-07-03 | — | — | CN | disclosed |
| WO-2020068951-A1 | COMPOSITIONS AND METHODS FOR REDUCING CALCIFICATION OF HEART VALVES | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2020-04-02 | — | — | WO | disclosed |
| WO-1999037151-A1 | METHOD AND COMPOSITIONS FOR PROMOTION OF WOUND HEALING | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1999-07-29 | — | — | WO | disclosed |
| WO-1999032605-A1 | METHOD FOR PRODUCING HETEROLOGOUS PROTEINS IN EUKARYOTIC CELLS ON AN INDUSTRIAL SCALE USING NUCLEOTIDE-MANIPULATING AGENTS | NOVO NORDISK A/S (DK) | 1999-07-01 | — | — | WO | disclosed |
| WO-1999023214-A1 | COMPOSITIONS AND METHODS FOR ENHANCING CARDIAC CONTRACTILITY MEDIATED BY MYOCYTE P2 PURINOCEPTORS AND MODELS THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1999-05-14 | — | — | WO | disclosed |
| WO-1999007877-A1 | BIOSENSOR FOR DETECTING ADENOSINE | THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS (GB) | 1999-02-18 | — | — | WO | disclosed |
| US-5712256-A | WOUND HEALING, YEASTS, ADENIN OR ADENOSINE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 1998-01-27 | — | — | US | disclosed |
| EP-0302807-B1 | Food products enriched with nucleosides and/or nucleotides and preparation thereof | PULEVA UNION IND AGRO GANADERA (ES) | 1994-01-19 | — | — | EP | disclosed |
| US-5227371-A | Utilization of adenine nucleotides and/or adenosine and inorganic phosphate for elevation of liver, blood and blood plasma adenosine 5'-triphosphate concentrations | RAPAPORT ELIEZER (US) | 1993-07-13 | — | — | US | disclosed |
| EP-0415018-A1 | Utilization of adenine nucleotides and/or adenosine and inorganic phosphate for elevation of liver, blood and blood plasma adenosine 5'-triphosphate concentrations | Rapaport, Eliezer (US) | 1991-03-06 | — | — | EP | disclosed |
| WO-1987007531-A1 | ENDOTOXIN REMOVAL | ROYAL POSTGRADUATE MEDICAL SCHOOL (GB) | 1987-12-17 | — | — | WO | disclosed |
| US-4650752-A | ELECTROCHEMICAL, RAPID, ACCURATE | ORIENTAL YEAST CO. LTD. (JP) | 1987-03-17 | — | — | US | disclosed |