Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831264 | 0.86 | KCNH2 (0.40) | CACNA1HKCNH2DDR1CACNA1INPC1 | |
| SCHEMBL3827234 | 0.86 | KCNH2 (0.40) | CACNA1HKCNH2DDR1CACNA1INPC1 | |
| SCHEMBL3827185 | 0.81 | NPC1 (0.43) | KCNH2NPC1CACNA1GKDM4EGAA | |
| SCHEMBL3824148 | 0.81 | KCNH2 (0.46) | CACNA1HKCNH2CACNA1ICACNA1GCHRM2 | |
| SCHEMBL3830150 | 0.80 | KCNH2 (0.42) | CACNA1HKCNH2DDR1CACNA1ICACNA1G | |
| SCHEMBL3830817 | 0.79 | KCNH2 (0.51) | CACNA1HKCNH2CACNA1ICACNA1GCHRM2 | |
| SCHEMBL3830481 | 0.78 | CACNA1H (0.41) | CACNA1HKCNH2NPC1CACNA1GKDM4E | |
| SCHEMBL3827202 | 0.78 | KCNH2 (0.41) | CACNA1HKCNH2CACNA1ICACNA1GCHRM2 | |
| SCHEMBL3824456 | 0.77 | KCNH2 (0.44) | CACNA1HKCNH2CACNA1ICACNA1GCHRM2 | |
| SCHEMBL3824215 | 0.77 | KCNH2 (0.44) | CACNA1HKCNH2CACNA1ICACNA1GCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896414-A4 | 3-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO INC (US) | 2009-09-09 | — | — | EP | claimed |
| EP-1896414-A2 | 3-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2008-03-12 | — | — | EP | claimed |
| WO-2007002361-A2 | 3-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | claimed |
| EP-1896414-A4 | 3-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-1896414-A2 | 3-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007002361-A2 | 3-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |