Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 4/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.49 |
| ▸ | BCR | P11274 | 2/20 | 0.49 |
| ▸ | BMX | P51813 | 2/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825966 | 0.92 | TNK2 (0.53) | TNK2MAP4K2ABL1BCRBMX | |
| SCHEMBL3825109 | 0.89 | TNK2 (0.54) | TNK2MAP4K2ABL1BCRBMX | |
| SCHEMBL3825129 | 0.89 | ABL1 (0.49) | TNK2MAP4K2ABL1BCRBMX | |
| SCHEMBL3827877 | 0.88 | TNK2 (0.56) | TNK2MAP4K2ABL1BCRBMX | |
| SCHEMBL3825269 | 0.88 | ABL1 (0.52) | TNK2MAP4K2ABL1BCRBMX | |
| SCHEMBL3825060 | 0.88 | TNK2 (0.52) | TNK2MAP4K2ABL1BCRBMX | |
| SCHEMBL3830962 | 0.87 | CSF1R (0.57) | TNK2MAP4K2ABL1BCRBMX | |
| SCHEMBL3829290 | 0.86 | TNK2 (0.63) | TNK2MAP4K2ABL1BCRBMX | |
| SCHEMBL3831469 | 0.86 | TNK2 (0.54) | TNK2MAP4K2ABL1BCRBMX | |
| SCHEMBL3827671 | 0.86 | TNK2 (0.56) | TNK2MAP4K2ABL1BCRBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | claimed |
| JP-2007500725-A | — | — | 2007-01-18 | — | — | JP | claimed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | claimed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | claimed |