Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.55 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.45 |
| ▸ | TEK | Q02763 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | FES | P07332 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.45 |
| ▸ | BMX | P51813 | 1/20 | 0.45 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3827892 | 0.87 | TNK2 (0.56) | CSF1RTNK2MAP4K2KDRPDGFRB | |
| SCHEMBL3831601 | 0.84 | TNK2 (0.49) | CSF1RTNK2MAP4K2KDRPDGFRB | |
| SCHEMBL3135987 | 0.82 | TNK2 (0.69) | CSF1RTNK2MAP4K2KDRPDGFRB | |
| SCHEMBL3824576 | 0.81 | TNK2 (0.63) | CSF1RTNK2MAP4K2KDRPDGFRB | |
| SCHEMBL3825775 | 0.79 | TNK2 (0.56) | CSF1RTNK2MAP4K2ABL1BRAF | |
| SCHEMBL3139856 | 0.77 | ABL1 (0.73) | TNK2MAP4K2KDRPDGFRBABL1 | |
| SCHEMBL3825439 | 0.76 | ABL1 (0.46) | TNK2MAP4K2KDRPDGFRBABL1 | |
| SCHEMBL3866214 | 0.76 | TNK2 (0.57) | TNK2MAP4K2KDRPDGFRBABL1 | |
| SCHEMBL3830363 | 0.75 | BRAF (0.51) | CSF1RTNK2MAP4K2KDRPDGFRB | |
| SCHEMBL3829526 | 0.73 | TNK2 (0.65) | TNK2MAP4K2KDRPDGFRBABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | claimed |
| JP-2007500725-A | — | — | 2007-01-18 | — | — | JP | claimed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | claimed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | claimed |