Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 15/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3813366 | 0.94 | CYP19A1 (1.00) | CYP19A1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3810768 | 0.92 | CYP19A1 (0.86) | CYP19A1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3811424 | 0.91 | CYP19A1 (1.00) | CYP19A1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3821126 | 0.90 | CYP19A1 (1.00) | CYP19A1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3817297 | 0.89 | CYP19A1 (1.00) | CYP19A1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15061273 | 0.88 | CYP19A1 (1.00) | CYP19A1 | |
| SCHEMBL15061556 | 0.86 | CYP19A1 (1.00) | CYP19A1ALDH1A1CYP2C9CYP2C19CA1 | |
| SCHEMBL3815332 | 0.84 | CYP19A1 (0.73) | CYP19A1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3833769 | 0.84 | CYP19A1 (0.77) | CYP19A1ALDH1A1CA1CA2CYP11B1 | |
| SCHEMBL3820682 | 0.84 | CYP19A1 (1.00) | CYP19A1ALDH1A1CYP2C9CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476313-B2 | Heteroaryl-containing isoflavones as aromatase inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-07-02 | — | — | US | disclosed |
| US-20090253715-A1 | HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-10-08 | — | — | US | disclosed |
| US-7572919-B2 | 7-Hydroxy-3-(4-hydroxyphenyl)-2-[(phenylmethyl)thio]-4H-1-benzopyran-4-one, for example; reacting deoxybenzoins with a phase transfer catalyst to provide a 2-(alkylthio)isoflavone, deprotecting the 2-(alkylthio)isoflavon, and applying selective debenzylation to form the final compound | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-08-11 | — | — | US | disclosed |
| US-20060183923-A1 | Heteroaryl-containing isoflavones as aromatase inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253715-A1 | HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS | CYP19A1, HSD17B11, CYP21A2 | CYP19A1 1/4885ALDH1A1 2575/4885CYP1A2 93/4885 |
| US-20060183923-A1 | Heteroaryl-containing isoflavones as aromatase inhibitors | CYP19A1, HSD17B11, CYP21A2 | CYP19A1 1/4885ALDH1A1 2575/4885CYP1A2 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.