Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 17/20 | 0.88 |
| ▸ | PRSS1 | P07477 | 16/20 | 0.88 |
| ▸ | PRSS2 | P07478 | 16/20 | 0.88 |
| ▸ | PRSS3 | P35030 | 16/20 | 0.88 |
| ▸ | F10 | P00742 | 12/20 | 0.88 |
| ▸ | F9 | P00740 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3831041 | 0.95 | F2 (0.79) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL3830164 | 0.94 | F10 (0.77) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL29457993 | 0.93 | F10 (1.00) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL3834806 | 0.91 | F2 (0.88) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL3836013 | 0.90 | F2 (0.82) | F2PRSS1PRSS2PRSS3F10 | |
| Trifluoroacetic Acid SCHEMBL3834109 | 0.86 | F2 (0.79) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL3833386 | 0.85 | F2 (0.79) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL3836037 | 0.84 | F2 (1.00) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL3830352 | 0.84 | F10 (0.67) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL3830092 | 0.82 | F10 (0.79) | F2PRSS1PRSS2PRSS3F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946508-B1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-09-23 | — | — | EP | claimed |
| US-6548512-B1 | Pyrazole derivatives such as 1-(3-amidinophenyl)-3-methyl-2-((5-(2'-aminosulfonylphenyl-1-yl)pyrimidin-2 -yl)aminocarbonyl)pyrazole; treating thromboembolic disorders | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-04-15 | — | — | US | claimed |
| EP-0946508-B1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-09-23 | — | — | EP | disclosed |
| US-6548512-B1 | Pyrazole derivatives such as 1-(3-amidinophenyl)-3-methyl-2-((5-(2'-aminosulfonylphenyl-1-yl)pyrimidin-2 -yl)aminocarbonyl)pyrazole; treating thromboembolic disorders | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-04-15 | — | — | US | disclosed |
| US-6020357-A | CARDIOVASCULAR DISORDERS; ANTCOAGULANTS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-02-01 | — | — | US | disclosed |