Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 1.00 |
| ▸ | EPHA2 | P29317 | 19/20 | 1.00 |
| ▸ | EPHB4 | P54760 | 15/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 12/20 | 1.00 |
| ▸ | FLT1 | P17948 | 8/20 | 1.00 |
| ▸ | GAK | O14976 | 1/20 | 0.75 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.75 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.75 |
| ▸ | STK10 | O94804 | 1/20 | 0.75 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.75 |
| ▸ | ABL1 | P00519 | 1/20 | 0.75 |
| ▸ | EGFR | P00533 | 1/20 | 0.75 |
| ▸ | LCK | P06239 | 1/20 | 0.75 |
| ▸ | YES1 | P07947 | 1/20 | 0.75 |
| ▸ | LYN | P07948 | 1/20 | 0.75 |
| ▸ | RET | P07949 | 1/20 | 0.75 |
| ▸ | HCK | P08631 | 1/20 | 0.75 |
| ▸ | BCR | P11274 | 1/20 | 0.75 |
| ▸ | SRC | P12931 | 1/20 | 0.75 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1791602 | 1.00 | KDR (1.00) | KDREPHA2EPHB4ERBB2FLT1 | |
| SCHEMBL1790263 | 1.00 | KDR (1.00) | KDREPHA2EPHB4ERBB2FLT1 | |
| SCHEMBL4383978 | 1.00 | KDR (1.00) | KDREPHA2EPHB4ERBB2FLT1 | |
| Hydrochloric Acid SCHEMBL1225046 | 0.99 | KDR (0.98) | KDREPHA2EPHB4ERBB2FLT1 | |
| Hydrochloric Acid SCHEMBL1225044 | 0.99 | KDR (0.98) | KDREPHA2EPHB4ERBB2FLT1 | |
| Hydrochloric Acid SCHEMBL907091 | 0.99 | KDR (0.98) | KDREPHA2EPHB4ERBB2FLT1 | |
| SCHEMBL907745 | 0.93 | EPHA2 (1.00) | KDREPHA2EPHB4ERBB2FLT1 | |
| SCHEMBL907749 | 0.93 | EPHA2 (1.00) | KDREPHA2EPHB4ERBB2FLT1 | |
| SCHEMBL907747 | 0.93 | EPHA2 (1.00) | KDREPHA2EPHB4ERBB2FLT1 | |
| SCHEMBL3029738 | 0.93 | EPHA2 (1.00) | KDREPHA2EPHB4ERBB2FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |