Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9407486 | 0.85 | KMT2A (0.55) | KMT2AMEN1MAPTATMANPEP | |
| SCHEMBL14243330 | 0.78 | MEN1 (0.48) | KMT2AMEN1MAPTATMANPEP | |
| SCHEMBL22605258 | 0.78 | MEN1 (0.48) | KMT2AMEN1MAPTATMANPEP | |
| SCHEMBL14228070 | 0.78 | MEN1 (0.48) | KMT2AMEN1MAPTATMANPEP | |
| SCHEMBL24059757 | 0.76 | MAPT (0.54) | KMT2AMEN1MAPTATMANPEP | |
| SCHEMBL9208437 | 0.76 | MAPT (0.54) | KMT2AMEN1MAPTATMANPEP | |
| SCHEMBL5586143 | 0.76 | KMT2A (0.46) | KMT2AMEN1MAPTATMANPEP | |
| SCHEMBL6450923 | 0.76 | KMT2A (0.46) | KMT2AMEN1MAPTATMANPEP | |
| SCHEMBL7045601 | 0.76 | KMT2A (0.46) | KMT2AMEN1MAPTATMANPEP | |
| SCHEMBL6442177 | 0.76 | KMT2A (0.46) | KMT2AMEN1MAPTATMANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102215-A1 | 4,5,6,7-TETRAHYDRO-THIENO [2,3-C]PYRIDINES AS H3 MODULATORS | F. Hoffmann-Roche AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| EP-2102214-A1 | 4, 5, 6, 7-TETRAHYDRO-THIENO [3, 2-C] PYRIDINE DERIVATIVES AS H3 MODULATORS | F. Hoffmann-Roche AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008068173-A9 | 4, 5, 6, 7-TETRAHYDRO-THIENO [3, 2-C] PYRIDINE DERIVATIVES AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-06-25 | — | — | WO | disclosed |
| WO-2008068174-A9 | 4,5,6,7-TETRAHYDRO-THIENO [2,3-C] PYRIDINES AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-06-18 | — | — | WO | disclosed |
| WO-2008068174-A1 | 4,5,6,7-TETRAHYDRO-THIENO [2,3-C] PYRIDINES AS H3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008068173-A1 | 4, 5, 6, 7-TETRAHYDRO-THIENO [3, 2-C] PYRIDINE DERIVATIVES AS H3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |