Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.51 |
| ▸ | LCK | P06239 | 8/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.50 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | BMX | P51813 | 2/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | BLK | P51451 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3824862 | 0.93 | BTK (0.53) | BTKLCKTNK2MAP4K2ABL1 | |
| SCHEMBL3830617 | 0.91 | TNK2 (0.53) | BTKLCKTNK2MAP4K2ABL1 | |
| SCHEMBL3829301 | 0.82 | BTK (0.55) | BTKLCKTNK2MAP4K2ABL1 | |
| SCHEMBL3825487 | 0.82 | JAK2 (0.54) | BTKLCKTNK2MAP4K2ABL1 | |
| SCHEMBL3825165 | 0.82 | BTK (0.55) | BTKLCKTNK2MAP4K2ABL1 | |
| SCHEMBL3825557 | 0.82 | JAK2 (0.54) | BTKLCKTNK2MAP4K2ABL1 | |
| SCHEMBL3829290 | 0.82 | TNK2 (0.63) | BTKLCKTNK2MAP4K2ABL1 | |
| SCHEMBL3135727 | 0.82 | TNK2 (0.53) | BTKLCKTNK2MAP4K2ABL1 | |
| SCHEMBL3132833 | 0.82 | SYK (0.59) | BTKLCKTNK2MAP4K2ABL1 | |
| SCHEMBL3829532 | 0.81 | BTK (0.46) | BTKLCKTNK2MAP4K2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | claimed |
| JP-2007500725-A | — | — | 2007-01-18 | — | — | JP | claimed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | claimed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | claimed |