Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.54 |
| ▸ | JAK2 | O60674 | 7/20 | 0.54 |
| ▸ | LCK | P06239 | 4/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | BMX | P51813 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829420 | 0.95 | LCK (0.55) | SRCJAK2LCKMAPK14TNK2 | |
| SCHEMBL3831040 | 0.89 | JAK2 (0.53) | SRCJAK2LCKMAPK14TNK2 | |
| SCHEMBL3825427 | 0.89 | JAK2 (0.53) | SRCJAK2LCKMAPK14TNK2 | |
| SCHEMBL3829311 | 0.88 | JAK2 (0.52) | SRCJAK2LCKMAPK14TNK2 | |
| SCHEMBL3825487 | 0.88 | JAK2 (0.54) | SRCJAK2LCKTNK2MAP4K2 | |
| SCHEMBL3824938 | 0.87 | LCK (0.52) | SRCJAK2LCKMAPK14TNK2 | |
| SCHEMBL3825165 | 0.87 | BTK (0.55) | SRCJAK2LCKTNK2MAP4K2 | |
| SCHEMBL3873074 | 0.86 | TNK2 (0.50) | SRCJAK2LCKMAPK14TNK2 | |
| SCHEMBL3832232 | 0.86 | SRC (0.51) | SRCJAK2LCKTNK2MAP4K2 | |
| SCHEMBL3825557 | 0.86 | JAK2 (0.54) | SRCJAK2LCKTNK2MAP4K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | disclosed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | disclosed |