Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
| ▸ | LDHB | P07195 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3148796 | 0.89 | TDP1 (0.63) | TDP1HSD17B10LMNAALOX15BLM | |
| Ethyl Chloride SCHEMBL15846117 | 0.88 | — | — | |
| Ammonia Solution, Strong SCHEMBL22023209 | 0.87 | TDP1 (0.60) | TDP1HSD17B10LMNAALOX15BLM | |
| Chloromethane SCHEMBL3624400 | 0.84 | — | — | |
| SCHEMBL14870 | 0.84 | — | — | |
| SCHEMBL2128293 | 0.84 | TDP1 (1.00) | TDP1HSD17B10LMNAALOX15BLM | |
| SCHEMBL5708652 | 0.84 | TDP1 (1.00) | TDP1HSD17B10LMNAALOX15BLM | |
| Butyl Chloride SCHEMBL15846373 | 0.83 | TDP1 (0.55) | TDP1HSD17B10ALDH1A1TSHR | |
| Trimethylammonium SCHEMBL2433318 | 0.83 | TDP1 (0.55) | TDP1HSD17B10LMNAALOX15BLM | |
| Propane SCHEMBL22974974 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099794-B1 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2099794-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008079873-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-03 | — | — | WO | disclosed |