Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.80 |
| ▸ | MAP2K2 | P36507 | 18/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | ACTR3 | P61158 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4578349 | 0.95 | MAP2K2 (0.83) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL29413364 | 0.89 | MAP2K2 (1.00) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL1488038 | 0.89 | MAP2K2 (1.00) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL3832369 | 0.89 | MAP2K2 (0.76) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL3833857 | 0.88 | MAP2K1 (0.84) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL29413626 | 0.88 | MAP2K1 (0.83) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL1488556 | 0.88 | MAP2K1 (0.83) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL3869042 | 0.87 | MAP2K1 (0.82) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL3834406 | 0.87 | MAP2K2 (0.77) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL188803 | 0.87 | MAP2K2 (0.83) | MAP2K1MAP2K2CHRM2CHRM1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934174-A1 | AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2008-06-25 | — | — | EP | claimed |
| WO-2007044515-A1 | AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | claimed |
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |