Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | BTK | Q06187 | 3/20 | 0.39 |
| ▸ | TXK | P42681 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825428 | 0.90 | NTRK1 (0.49) | NTRK1KDRJAK3BTKTXK | |
| SCHEMBL2065418 | 0.81 | KDR (0.41) | NTRK1KDRJAK3BTKTXK | |
| SCHEMBL3844605 | 0.80 | SRC (0.54) | KDRJAK2JAK3BTKTXK | |
| SCHEMBL3832186 | 0.76 | NTRK1 (0.47) | NTRK1KDRJAK3BTKTXK | |
| SCHEMBL3832202 | 0.75 | NTRK1 (0.50) | NTRK1KDRLCK | |
| SCHEMBL2065481 | 0.75 | KDR (0.47) | NTRK1KDRJAK3BTKTXK | |
| SCHEMBL2068462 | 0.75 | NTRK1 (0.41) | NTRK1KDRJAK3BTKTXK | |
| SCHEMBL2065432 | 0.74 | KDR (0.39) | NTRK1KDRJAK3BTKTXK | |
| SCHEMBL3827871 | 0.74 | NTRK1 (0.38) | NTRK1KDRJAK3BTK | |
| SCHEMBL2065977 | 0.74 | KDR (0.40) | NTRK1KDRJAK3BTKTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099794-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008079873-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-03 | — | — | WO | disclosed |