Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 3/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831259 | 0.91 | NPC1 (0.42) | POLBNPC1ALDH1A1ADRB2SCD5 | |
| SCHEMBL3832549 | 0.86 | NPC1 (0.44) | POLBNPC1ALDH1A1SCD5SGMS2 | |
| SCHEMBL1202926 | 0.85 | NPC1 (0.46) | POLBNPC1ALDH1A1SCD5SGMS2 | |
| SCHEMBL3830626 | 0.84 | NPC1 (0.42) | POLBNPC1ALDH1A1SCD5SGMS2 | |
| SCHEMBL3829469 | 0.83 | NPC1 (0.45) | POLBNPC1ALDH1A1SCD5SGMS2 | |
| SCHEMBL3831171 | 0.82 | NPC1 (0.41) | POLBNPC1ALDH1A1SCD5HTT | |
| SCHEMBL3831176 | 0.81 | NTRK1 (0.52) | POLBNPC1ALDH1A1ADRB2SCD5 | |
| SCHEMBL3826432 | 0.81 | NPC1 (0.46) | POLBNPC1ALDH1A1ADRB2SCD5 | |
| SCHEMBL3830782 | 0.81 | NPC1 (0.43) | POLBNPC1ALDH1A1SCD5SGMS2 | |
| SCHEMBL27637724 | 0.81 | NPC1 (0.51) | POLBNPC1ALDH1A1SCD5SGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1460071-B1 | N-HETEROARYLNICOTINAMIDE DERIVATIVES | MITSUI CHEMICALS AGRO INC (JP) | 2009-09-16 | — | — | EP | disclosed |
| US-7015236-B2 | N-heteroarylnicotinamide derivatives | SANKYO AGRO COMPANY, LIMITED (JP) | 2006-03-21 | — | — | US | disclosed |
| US-20050004368-A1 | N-heteroarylnicotinamide derivatives | SANKYO ARGO COMPANY LIMITED (JP) | 2005-01-06 | — | — | US | disclosed |
| EP-1460071-A1 | N-HETEROARYLNICOTINAMIDE DERIVATIVES | Sankyo Agro Company, Limited (JP) | 2004-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004368-A1 | N-heteroarylnicotinamide derivatives | CBR3, CBR1, NAT1 | POLB 3500/4885NPC1 673/4885ALDH1A1 926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.