SCHEMBL3833331

SCHEMBL3833331

CCCC(=O)NS(=O)(=O)c1ccc(NC(=O)Cc2ccc(Cl)c(Oc3cc(Cl)cc(C#N)c3)c2F)c(C)c1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.41
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
AKR1C3 P42330 1/20 0.36
AKR1C2 P52895 1/20 0.36
SLC22A12 Q96S37 1/20 0.35
RORC P51449 5/20 0.34
EPAS1 Q99814 1/20 0.33
ALDH1A1 P00352 1/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.33
IDO1 P14902 1/20 0.32
MCL1 Q07820 1/20 0.32
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2638996 0.94 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19AKR1C3AKR1C2
SCHEMBL2639819 0.94 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19AKR1C3AKR1C2
SCHEMBL3833330 0.91 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19AKR1C3AKR1C2
SCHEMBL2638934 0.90 CYP3A4 (0.45) CYP3A4CYP2C9CYP2C19SLC22A12RORC
SCHEMBL2638836 0.90 CYP3A4 (0.41) CYP3A4CYP2C9CYP2C19AKR1C3AKR1C2
SCHEMBL2638424 0.88 CYP3A4 (0.43) CYP3A4CYP2C9CYP2C19AKR1C3AKR1C2
SCHEMBL2639007 0.88 CYP3A4 (0.44) CYP3A4CYP2C9CYP2C19
SCHEMBL2641329 0.87 CYP3A4 (0.39) CYP3A4CYP2C9CYP2C19AKR1C3AKR1C2
SCHEMBL2638236 0.87 CYP3A4 (0.39) CYP3A4CYP2C9CYP2C19AKR1C3AKR1C2
SCHEMBL2638965 0.87 CYP3A4 (0.41) CYP3A4CYP2C9CYP2C19AKR1C3AKR1C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1742908-B1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-11-11 EP claimed