Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3833949 | 0.94 | GRM5 (0.58) | GRM5LMNATP53CES2THRB | |
| SCHEMBL3836518 | 0.90 | GRM5 (0.57) | GRM5CES2 | |
| SCHEMBL3832229 | 0.89 | GRM5 (0.60) | GRM5TP53CES2 | |
| SCHEMBL3834589 | 0.89 | GRM5 (0.58) | GRM5LMNATP53CES2THRB | |
| SCHEMBL13677021 | 0.88 | GRM5 (0.70) | GRM5CES2 | |
| SCHEMBL13677018 | 0.88 | GRM5 (0.61) | GRM5TP53CES2 | |
| SCHEMBL3836170 | 0.88 | GRM5 (0.69) | GRM5CES2 | |
| SCHEMBL3832691 | 0.88 | GRM5 (0.61) | GRM5CES2 | |
| SCHEMBL13677017 | 0.87 | GRM5 (0.65) | GRM5CES2 | |
| SCHEMBL13677019 | 0.87 | GRM5 (0.71) | GRM5LMNATP53CES2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962849-B1 | QUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF MGLUR5 RECEPTOR-MEDIATED DISORDERS | RICHTER GEDEON NYRT (HU) | 2009-09-30 | — | — | EP | claimed |