Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.35 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 8/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.33 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG | P07510 | 1/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3834266 | 1.00 | KCNQ3 (0.35) | KCNQ3KCNQ2KCNE1KCNQ1KMT2A | |
| SCHEMBL3827291 | 0.85 | NPSR1 (0.36) | KCNQ3KCNQ2KCNE1KCNQ1KMT2A | |
| SCHEMBL3833887 | 0.85 | NPSR1 (0.36) | KCNQ3KCNQ2KCNE1KCNQ1KMT2A | |
| SCHEMBL3833981 | 0.80 | CNR1 (0.41) | KMT2AMDM2MAPK1ALDH1A1MEN1 | |
| SCHEMBL3833984 | 0.80 | CNR1 (0.41) | KMT2AMDM2MAPK1ALDH1A1MEN1 | |
| SCHEMBL3827551 | 0.79 | TP53 (0.34) | KMT2ATP53MDM2CHRNB2CHRNA4 | |
| SCHEMBL13567978 | 0.79 | KMT2A (0.35) | KMT2ATP53MAPK1ALDH1A1MEN1 | |
| SCHEMBL3827553 | 0.79 | TP53 (0.34) | KMT2ATP53MDM2CHRNB2CHRNA4 | |
| SCHEMBL2487546 | 0.77 | NPSR1 (0.34) | KCNQ3KCNQ2KCNE1KCNQ1TP53 | |
| SCHEMBL3831124 | 0.77 | NPSR1 (0.34) | KCNQ3KCNQ2KCNE1KCNQ1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312310-A1 | Imidazothiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-12-17 | — | — | US | disclosed |
| EP-2103619-A1 | IMIDAZOTHIAZOLE DERIVATIVES | Daiichi Sankyo Company, Limited (JP) | 2009-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312310-A1 | Imidazothiazole derivatives | TP53, MDM2, TP53BP1 | KCNQ3 4627/4885KCNQ2 4248/4885KCNE1 3257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.