SCHEMBL3834635

SCHEMBL3834635

COC(=O)c1cc(C)nn1-c1cccc(C#N)c1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
F10 P00742 1/20 0.53
ALDH1A1 P00352 2/20 0.45
ADORA2A P29274 1/20 0.43
NOTUM Q6P988 1/20 0.43
KMT2A Q03164 4/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
MDM2 Q00987 1/20 0.42
FLT3 P36888 1/20 0.42
TSHR P16473 2/20 0.42
MEN1 O00255 1/20 0.42
TP53 P04637 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
HSD17B10 Q99714 1/20 0.41
NPBWR1 P48145 1/20 0.41
MCHR1 Q99705 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23429155 0.88 F10 (0.53) F10ALDH1A1ADORA2ANOTUMKMT2A
SCHEMBL3833007 0.88 KMT2A (0.51) F10ALDH1A1KMT2ASMN1; SMN2
SCHEMBL31067538 0.88 KMT2A (0.51) F10ALDH1A1KMT2ASMN1; SMN2
SCHEMBL1680141 0.86 F10 (0.53) F10ALDH1A1ADORA2ANOTUMKMT2A
SCHEMBL3833366 0.85 F10 (0.48) F10ALDH1A1ADORA2ANOTUMKMT2A
Hydrochloric Acid SCHEMBL3830146 0.85 F10 (0.52) F10ALDH1A1ADORA2ANOTUMKMT2A
SCHEMBL15428605 0.85 F10 (0.55) F10ALDH1A1ADORA2ANOTUMKMT2A
SCHEMBL3830143 0.85 F10 (0.52) F10ALDH1A1ADORA2ANOTUMKMT2A
SCHEMBL3833364 0.84 SMN1; SMN2 (0.41) F10ALDH1A1NOTUMKMT2ASMN1; SMN2
SCHEMBL21100762 0.83 KLKB1 (0.53)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0946508-B1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS BRISTOL MYERS SQUIBB PHARMA CO (US) 2009-09-23 EP disclosed
US-6548512-B1 Pyrazole derivatives such as 1-(3-amidinophenyl)-3-methyl-2-((5-(2'-aminosulfonylphenyl-1-yl)pyrimidin-2 -yl)aminocarbonyl)pyrazole; treating thromboembolic disorders BRISTOL-MYERS SQUIBB PHARMA COMPANY 2003-04-15 US disclosed
US-6020357-A CARDIOVASCULAR DISORDERS; ANTCOAGULANTS DUPONT PHARMACEUTICALS COMPANY (US) 2000-02-01 US disclosed
EP-0946508-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS Du Pont Pharmaceuticals Company (US) 1999-10-06 EP disclosed
WO-1998028269-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1998-07-02 WO disclosed