Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 18/20 | 0.61 |
| ▸ | PLG | P00747 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831661 | 0.86 | F10 (0.60) | KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL3833446 | 0.83 | F10 (0.67) | KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL20579663 | 0.83 | KLKB1 (0.60) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL3829467 | 0.82 | KLKB1 (0.61) | KLKB1PRSS1PRSS2PRSS3CARM1 | |
| SCHEMBL17064351 | 0.81 | KLKB1 (0.66) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL17064559 | 0.80 | KLKB1 (0.72) | KLKB1 | |
| SCHEMBL17065090 | 0.80 | KLKB1 (0.72) | KLKB1 | |
| SCHEMBL31744214 | 0.80 | KLKB1 (0.72) | KLKB1 | |
| SCHEMBL21100632 | 0.80 | KLKB1 (0.64) | KLKB1CARM1 | |
| SCHEMBL3831242 | 0.80 | F10 (0.71) | KLKB1PRSS1PRSS2PRSS3CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946508-B1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-09-23 | — | — | EP | disclosed |
| CN-1246847-A | Nitrogen containing heteroaromatics as factor Xa inhibitors | DU PONT MERCK PHARMA (US) | 2000-03-08 | — | — | CN | disclosed |
| US-6020357-A | CARDIOVASCULAR DISORDERS; ANTCOAGULANTS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-02-01 | — | — | US | disclosed |
| EP-0946508-A1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | Du Pont Pharmaceuticals Company (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028269-A1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-07-02 | — | — | WO | disclosed |