Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8035024 | 0.86 | EDNRA (0.41) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3835067 | 0.80 | EDNRA (0.72) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3835069 | 0.80 | EDNRA (0.72) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3839122 | 0.79 | EDNRA (0.65) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3838925 | 0.79 | EDNRA (0.46) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7501847 | 0.77 | EDNRA (0.58) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3836955 | 0.76 | HSP90AA1 (0.38) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6580603 | 0.76 | EDNRA (0.47) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3838481 | 0.73 | HSP90AA1 (0.37) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3856293 | 0.73 | EDNRA (0.43) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861247-B1 | NOVEL IMIDAZOLE N-BENZYLDIOXOL DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | AVENTIS PHARMA SA (FR) | 2009-10-07 | — | — | EP | disclosed |
| EP-0861247-A1 | NOVEL IMIDAZOLE N-BENZYLDIOXOL DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | HOECHST MARION ROUSSEL (FR) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997017339-A1 | NOVEL IMIDAZOLE N-BENZYLDIOXOL DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | HOECHST MARION ROUSSEL (FR) | 1997-05-15 | — | — | WO | disclosed |