Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 15/20 | 0.59 |
| ▸ | F2 | P00734 | 11/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 10/20 | 0.59 |
| ▸ | PRSS3 | P35030 | 10/20 | 0.59 |
| ▸ | F9 | P00740 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3833321 | 0.95 | F10 (0.63) | F10F2PRSS1PRSS2PRSS3 | |
| Trifluoroacetic Acid SCHEMBL3830432 | 0.87 | KLKB1 (0.51) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3830087 | 0.87 | F10 (0.63) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3830187 | 0.85 | F10 (0.72) | F10F2PRSS1PRSS2PRSS3 | |
| Trifluoroacetic Acid SCHEMBL3830314 | 0.84 | F10 (0.57) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3830373 | 0.82 | F10 (0.54) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3831670 | 0.80 | F10 (0.53) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3830129 | 0.80 | F10 (0.60) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3834867 | 0.79 | F10 (0.68) | F10F2PRSS1PRSS2PRSS3 | |
| Trifluoroacetic Acid SCHEMBL3829623 | 0.78 | F10 (0.65) | F10F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946508-B1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-09-23 | — | — | EP | disclosed |
| US-6548512-B1 | Pyrazole derivatives such as 1-(3-amidinophenyl)-3-methyl-2-((5-(2'-aminosulfonylphenyl-1-yl)pyrimidin-2 -yl)aminocarbonyl)pyrazole; treating thromboembolic disorders | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-04-15 | — | — | US | disclosed |
| US-6020357-A | CARDIOVASCULAR DISORDERS; ANTCOAGULANTS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-02-01 | — | — | US | disclosed |