Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 7/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 2/20 | 0.31 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3050289 | 0.89 | BRD4 (0.38) | NR1H2BRD4CREBBPATRATRIP | |
| SCHEMBL3051063 | 0.87 | BRD4 (0.37) | NR1H2BRD4CREBBPATRATRIP | |
| SCHEMBL3046227 | 0.85 | NR1H2 (0.38) | NR1H2BRD4CREBBPATRATRIP | |
| SCHEMBL3043890 | 0.84 | BRD4 (0.38) | NR1H2BRD4CREBBPATRATRIP | |
| SCHEMBL3040861 | 0.83 | ATR (0.34) | NR1H2BRD4CREBBPATRATRIP | |
| SCHEMBL3044207 | 0.83 | NR1H2 (0.38) | NR1H2BRD4CREBBPATRATRIP | |
| SCHEMBL3837222 | 0.82 | NR1H2 (0.34) | NR1H2ATRATRIP | |
| SCHEMBL3041655 | 0.82 | NR1H2 (0.38) | NR1H2BRD4CREBBPATRATRIP | |
| SCHEMBL3048395 | 0.80 | NR1H2 (0.37) | NR1H2BRD4CREBBPATRATRIP | |
| SCHEMBL3034057 | 0.80 | NR1H2 (0.35) | NR1H2BRD4CREBBPATRATRIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |