Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.42 |
| ▸ | ITK | Q08881 | 12/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | TEC | P42680 | 1/20 | 0.38 |
| ▸ | TXK | P42681 | 1/20 | 0.38 |
| ▸ | BMX | P51813 | 1/20 | 0.38 |
| ▸ | CD69 | Q07108 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656118 | 0.84 | EGFR (0.47) | EGFRITKBTKSYKAURKA | |
| SCHEMBL656581 | 0.83 | EGFR (0.49) | EGFRITKBTKSYKAURKA | |
| SCHEMBL3838652 | 0.82 | SYK (0.49) | EGFRITKBTKSYK | |
| SCHEMBL657968 | 0.81 | EGFR (0.50) | EGFRITKBTKSYKAURKA | |
| SCHEMBL656244 | 0.81 | EGFR (0.45) | EGFRITKBTKSYKAURKA | |
| SCHEMBL3834043 | 0.80 | EGFR (0.62) | EGFRITKBTKSYK | |
| SCHEMBL657554 | 0.77 | SYK (0.50) | EGFRITKSYKAURKA | |
| SCHEMBL656773 | 0.75 | SYK (0.69) | SYKAURKA | |
| SCHEMBL656709 | 0.75 | EGFR (0.44) | EGFRITKBTKSYKAURKA | |
| SCHEMBL657135 | 0.75 | SYK (0.53) | EGFRITKBTKSYKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2130541-A2 | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds | Rigel Pharmaceuticals, Inc. (US) | 2009-12-09 | — | — | EP | claimed |