SCHEMBL3836020

SCHEMBL3836020

O=C(Cl)Oc1ccc(-n2[nH]cc(-c3cccnc3)c2=O)nc1

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
P4HTM Q9NXG6 13/20 0.67
VHL P40337 7/20 0.64
EGLN1 Q9GZT9 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17938039 0.90 P4HTM (0.69) P4HTMVHLEGLN1
Hydrochloric Acid SCHEMBL3842101 0.88 P4HTM (0.66) P4HTMVHLEGLN1
SCHEMBL17938031 0.84 P4HTM (0.70) P4HTMVHLEGLN1
SCHEMBL3617392 0.84 P4HTM (0.70) P4HTMVHLEGLN1
Hydrochloric Acid SCHEMBL17938049 0.83 P4HTM (0.69) P4HTMVHLEGLN1
SCHEMBL3591779 0.82 VHL (0.71) P4HTMVHLEGLN1
SCHEMBL3599948 0.81 P4HTM (0.72) P4HTMVHLEGLN1
SCHEMBL3619683 0.81 P4HTM (1.00) P4HTMVHLEGLN1
SCHEMBL8186022 0.80 VHL (0.71) P4HTMVHLEGLN1
SCHEMBL3595365 0.80 VHL (0.71) P4HTMVHLEGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2097404-B1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF BAYER IP GMBH (DE) 2016-07-27 EP disclosed
EP-2097404-A1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF Bayer HealthCare AG (DE) 2009-09-09 EP disclosed
WO-2008067874-A1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-06-12 WO disclosed