Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 8/20 | 0.56 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839363 | 0.86 | SCD (0.61) | SCDPPARALMNAMAPT | |
| SCHEMBL3042841 | 0.83 | SCD (0.55) | SCDPPARASMN1; SMN2RAB9AKDM4E | |
| SCHEMBL3047634 | 0.79 | SCD (0.75) | SCDPPARALMNAMAPT | |
| SCHEMBL3044261 | 0.78 | SCD (0.68) | SCDPPARALMNAMAPT | |
| SCHEMBL3045493 | 0.76 | SCD (0.62) | SCDPPARALMNAMAPT | |
| SCHEMBL3035795 | 0.76 | SCD (0.65) | SCDPPARALMNAMAPT | |
| SCHEMBL15484693 | 0.75 | SCD (0.64) | SCDPPARALMNAMAPT | |
| SCHEMBL3049398 | 0.74 | SCD (0.59) | SCDPPARALMNAMAPT | |
| SCHEMBL3044560 | 0.73 | SCD (0.64) | SCDPPARALMNAMAPT | |
| SCHEMBL3045700 | 0.73 | SCD (0.84) | SCDSMN1; SMN2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086970-A2 | 2-(PYRAZIN-2-YL)-THIAZOLE AND 2-(1H PYRAZOL-3-YL)-THIAZOLE DERIVATIVES AS WELL AS RELATED COMPOUNDS AS STEAROYL-COA DESATURASE (SCD) INHIBITORS FOR THE TREATMENT OF METABOLIC, CARDIOVASCULAR AND OTHER DISORDERS | Novartis AG (CH) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008024390-A2 | 2- (PYRAZIN-2-YL) -THIAZOLE AND 2- (1H-PYRAZ0L-3-YL) -THIAZOLE DERIVATIVES AS WELL AS RELATED COMPOUNDS AS STEAROYL-COA DESATURASE (SCD) INHIBITORS FOR THE TREATMENT OF METABOLIC, CARDIOVASCULAR AND OTHER DISORDERS | NOVARTIS AG (CH) | 2008-02-28 | — | — | WO | disclosed |