Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.43 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | MGMT | P16455 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 5/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.36 |
| ▸ | CDK2 | P24941 | 5/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 2/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29708075 | 1.00 | PDPK1 (0.43) | PDPK1GDAHPRT1KDRAURKB | |
| SCHEMBL3839818 | 0.93 | PDPK1 (0.41) | PDPK1GDAHPRT1KDRAURKB | |
| SCHEMBL30416490 | 0.88 | PDPK1 (0.41) | PDPK1GDAHPRT1KDRAURKB | |
| SCHEMBL8400853 | 0.83 | PDPK1 (0.40) | PDPK1GDAKDRAURKBMGMT | |
| SCHEMBL30416185 | 0.83 | PDPK1 (0.49) | PDPK1GDAHPRT1KDRAURKB | |
| SCHEMBL30687390 | 0.82 | PDPK1 (0.39) | PDPK1GDAKDRAURKBMGMT | |
| SCHEMBL8401394 | 0.82 | PDPK1 (0.38) | PDPK1GDAKDRAURKBMGMT | |
| SCHEMBL4364340 | 0.80 | PDPK1 (0.49) | PDPK1GDAMGMTCDK1CCNB1 | |
| SCHEMBL16038966 | 0.80 | FGFR1 (0.39) | HPRT1FGFR1SLC22A6PNP | |
| SCHEMBL7165317 | 0.80 | PDPK1 (0.51) | PDPK1GDACDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763424-A | SEQUESTERING AGENT | GILEAD SCIENCES, INC. (US) | 1998-06-09 | — | — | US | claimed |
| US-10195222-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-02-05 | — | — | US | disclosed |
| US-10076532-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-09-18 | — | — | US | disclosed |
| US-20180064737-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | UNIV CALIFORNIA (US) | 2018-03-08 | — | — | US | disclosed |
| US-20170304330-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-10-26 | — | — | US | disclosed |
| US-20170189430-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-07-06 | — | — | US | disclosed |
| US-9629860-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-04-25 | — | — | US | disclosed |
| US-20140274959-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) | 2014-09-18 | — | — | US | disclosed |
| EP-1732569-B1 | USE OF ADEFOVIR OR TENOFOVIR FOR INHIBITING MMTV-LIKE VIRUSES INVOLVED IN BREAST CANCER AND PRIMARY BILIARY CIRRHOSIS | GILEAD SCIENCES INC (US) | 2009-10-14 | — | — | EP | disclosed |
| US-20070281911-A1 | Use of Adefovir or Tenofovir for Inhibiting Mmtv-Like Viruses Involved in Breast Cancer and Primary Biliary Cirrhosis | GILEAD SCIENCES INC. (US) | 2007-12-06 | — | — | US | disclosed |
| EP-1732569-A1 | USE OF ADEFOVIR OR TENOFOVIR FOR INHIBITING MMTV-LIKE VIRUSES INVOLVED IN BREAST CANCER AND PRIMARY BILIARY CIRRHOSIS | GILEAD SCIENCES, INC. (US) | 2006-12-20 | — | — | EP | disclosed |
| US-20050239753-A1 | Methods of inhibition of MMTV-like viruses | GILEAD SCIENCES, INC. | 2005-10-27 | — | — | US | disclosed |
| WO-2005072748-A1 | USE OF ADEFOVIR OR TENOFOVIR FOR INHIBITING MMTV-LIKE VIRUSES INVOLVED IN BREAST CANCER AND PRIMARY BILIARY CIRRHOSIS | GILEAD SCIENCES, INC. (US) | 2005-08-11 | — | — | WO | disclosed |
| WO-2003028737-A1 | ANTI-VIRAL AGENTS AND IN-VITRO METHOD FOR THE IDENTIFICATION OF CANDIDATES ABLE TO INHIBIT BINDING OF POLYMERASE TO EPSILON | MITSUBISHI PHARMA CORPORATION (JP) | 2003-04-10 | — | — | WO | disclosed |
| US-5874577-A | Method for the preparing 9-12-(Diethoxyphosphonomethoxy)ethyl!adenine and analogues thereof | MEDICHEM RESEARCH, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5874577-A | Method for the preparing 9-12-(Diethoxyphosphonomethoxy)ethyl!adenine and analogues thereof | MEDICHEM RESEARCH, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5763424-A | SEQUESTERING AGENT | GILEAD SCIENCES, INC. (US) | 1998-06-09 | — | — | US | disclosed |
| WO-1996009307-A1 | PURINE AND 8-AZAPURINE DERIVATIVES SUITABLE TO THE THERAPEUTIC TREATMENT OF AIDS | ISTITUTO SUPERIORE DI SANITA' (IT) | 1996-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180064737-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | PDPK1 368/4885GDA 68/4885HPRT1 57/4885 |
| US-20170189430-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | PDPK1 368/4885GDA 68/4885HPRT1 57/4885 |
| US-20140274959-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | PDPK1 368/4885GDA 68/4885HPRT1 57/4885 |
| US-10195222-B2 | Acyclic nucleoside phosphonate diesters | NTPCR, PNP, TYMP | PDPK1 368/4885GDA 68/4885HPRT1 57/4885 |
| US-10076532-B2 | Acyclic nucleoside phosphonate diesters | NTPCR, PNP, TYMP | PDPK1 368/4885GDA 68/4885HPRT1 57/4885 |
| US-20170304330-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | PDPK1 368/4885GDA 68/4885HPRT1 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.