Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.49 |
| ▸ | EGFR | P00533 | 10/20 | 0.45 |
| ▸ | ITK | Q08881 | 3/20 | 0.45 |
| ▸ | BTK | Q06187 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL658177 | 0.92 | SYK (0.48) | SYKEGFRITKBTK | |
| SCHEMBL654902 | 0.89 | SYK (0.49) | SYKEGFRITKBTK | |
| SCHEMBL657558 | 0.88 | SYK (0.59) | SYKEGFRITKBTK | |
| Hydrochloric Acid SCHEMBL656794 | 0.88 | SYK (0.58) | SYKEGFRITKBTK | |
| Succinic Acid SCHEMBL657780 | 0.86 | SYK (0.57) | SYKEGFRITKBTK | |
| Fumaric Acid SCHEMBL658654 | 0.85 | SYK (0.56) | SYKEGFRITKBTK | |
| Maleic Acid SCHEMBL657015 | 0.85 | SYK (0.56) | SYKEGFRITKBTK | |
| Citric Acid SCHEMBL656798 | 0.83 | SYK (0.53) | SYKEGFRITKBTK | |
| SCHEMBL3839325 | 0.80 | EGFR (0.46) | SYKEGFRITKBTK | |
| SCHEMBL3836417 | 0.79 | EGFR (0.55) | SYKEGFRITKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2130541-A2 | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds | Rigel Pharmaceuticals, Inc. (US) | 2009-12-09 | — | — | EP | claimed |