Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.43 |
| ▸ | EGFR | P00533 | 12/20 | 0.41 |
| ▸ | ITK | Q08881 | 7/20 | 0.39 |
| ▸ | BCL6 | P41182 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656887 | 0.94 | SYK (0.42) | SYKEGFRITK | |
| SCHEMBL657282 | 0.88 | EGFR (0.45) | SYKEGFRITK | |
| SCHEMBL655923 | 0.77 | SYK (0.58) | SYKITK | |
| SCHEMBL657843 | 0.72 | SYK (0.40) | SYKEGFRITK | |
| SCHEMBL2104234 | 0.71 | BCL6 (0.66) | SYKEGFRITKBCL6 | |
| SCHEMBL4798452 | 0.71 | AURKA (0.43) | SYKEGFRITK | |
| SCHEMBL657554 | 0.70 | SYK (0.50) | SYKEGFRITK | |
| SCHEMBL27613085 | 0.70 | EGFR (0.54) | SYKEGFRITKBCL6 | |
| SCHEMBL656581 | 0.70 | EGFR (0.49) | SYKEGFRITK | |
| SCHEMBL657135 | 0.70 | SYK (0.53) | SYKEGFRITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2130541-A2 | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds | Rigel Pharmaceuticals, Inc. (US) | 2009-12-09 | — | — | EP | claimed |