Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639032 | 0.88 | P2RY12 (0.51) | P2RY12KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL27777390 | 0.87 | P2RY12 (0.54) | P2RY12KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1639752 | 0.83 | P2RY12 (0.54) | P2RY12KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1640201 | 0.83 | P2RY12 (0.68) | P2RY12KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1640891 | 0.83 | P2RY12 (0.57) | P2RY12KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1640864 | 0.83 | P2RY12 (0.53) | P2RY12KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1640735 | 0.82 | P2RY12 (0.52) | P2RY12KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL27756396 | 0.81 | P2RY12 (0.59) | P2RY12KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1640369 | 0.80 | P2RY12 (0.51) | P2RY12KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1640127 | 0.80 | P2RY12 (0.53) | P2RY12KDM4EALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094272-A2 | NITROGEN CONTAINING SUBSTITUTED HETEROCYCLES AS PLATELET ADP RECEPTOR INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008036843-A2 | NITROGEN CONTAINING SUBSTITUTED HETEROCYCLES AS PLATELET ADP RECEPTOR INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |