Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.71 |
| ▸ | CTSD | P07339 | 14/20 | 0.71 |
| ▸ | BACE2 | Q9Y5Z0 | 14/20 | 0.71 |
| ▸ | REN | P00797 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3534212 | 0.83 | BACE1 (1.00) | BACE1CTSDBACE2REN | |
| SCHEMBL3536710 | 0.83 | BACE1 (1.00) | BACE1CTSDBACE2REN | |
| SCHEMBL3532433 | 0.83 | BACE1 (1.00) | BACE1CTSDBACE2REN | |
| SCHEMBL3535491 | 0.82 | BACE1 (0.69) | BACE1CTSDBACE2RENABL1 | |
| SCHEMBL3533945 | 0.78 | BACE1 (0.77) | BACE1CTSDBACE2RENABL1 | |
| SCHEMBL3535575 | 0.73 | BACE1 (0.81) | BACE1CTSDBACE2REN | |
| SCHEMBL4065513 | 0.73 | BACE1 (0.77) | BACE1CTSDBACE2REN | |
| SCHEMBL8201098 | 0.72 | BACE1 (0.79) | BACE1CTSDBACE2REN | |
| SCHEMBL3533234 | 0.70 | BACE1 (0.77) | BACE1CTSDBACE2RENABL1 | |
| SCHEMBL4510675 | 0.69 | BACE1 (0.55) | BACE1CTSDBACE2RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756087-B1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | WYETH CORP (US) | 2009-10-07 | — | — | EP | claimed |