Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049397 | 0.89 | EDNRA (0.49) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7498348 | 0.85 | EDNRA (0.63) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3839122 | 0.84 | EDNRA (0.65) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8431142 | 0.83 | EDNRA (0.61) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3837125 | 0.82 | EDNRA (0.70) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7503964 | 0.82 | EDNRA (0.63) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8432727 | 0.80 | EDNRA (0.58) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7504056 | 0.79 | EDNRA (0.57) | EDNRAAGTR1AGTR2 | |
| SCHEMBL8431330 | 0.78 | EDNRA (0.56) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7501847 | 0.78 | EDNRA (0.58) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861247-B1 | NOVEL IMIDAZOLE N-BENZYLDIOXOL DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | AVENTIS PHARMA SA (FR) | 2009-10-07 | — | — | EP | disclosed |
| EP-0863896-B1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | AVENTIS PHARMA SA (FR) | 2005-02-09 | — | — | EP | disclosed |
| EP-0861247-A1 | NOVEL IMIDAZOLE N-BENZYLDIOXOL DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | HOECHST MARION ROUSSEL (FR) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997017339-A1 | NOVEL IMIDAZOLE N-BENZYLDIOXOL DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | HOECHST MARION ROUSSEL (FR) | 1997-05-15 | — | — | WO | disclosed |