Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSH | P09668 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837855 | 0.94 | GRM5 (0.48) | GRM5PIM1PIM2MEN1KMT2A | |
| SCHEMBL3836693 | 0.90 | GRM5 (0.47) | GRM5PIM1PIM2PTGES | |
| SCHEMBL3837876 | 0.83 | GRM5 (0.49) | GRM5NPC1RAB9AALDH1A1 | |
| SCHEMBL3835800 | 0.79 | GRM5 (0.45) | GRM5PIM1PIM2PTGES | |
| SCHEMBL3836465 | 0.79 | GRM5 (0.47) | GRM5PIM1KCNH2 | |
| SCHEMBL3839809 | 0.79 | GRM5 (0.50) | GRM5PTGESKCNH2 | |
| SCHEMBL3838272 | 0.79 | GRM5 (0.50) | GRM5PTGESKCNH2 | |
| SCHEMBL3839812 | 0.79 | GRM5 (0.50) | GRM5PTGESKCNH2 | |
| SCHEMBL3835093 | 0.78 | GRM5 (0.44) | GRM5PIM1PIM2PTGESNPC1 | |
| SCHEMBL3836423 | 0.77 | GRM5 (0.58) | GRM5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877367-B1 | ACETYLENE DERIVATIVES | NOVARTIS AG (CH) | 2009-10-14 | — | — | EP | claimed |
| EP-1877367-B1 | ACETYLENE DERIVATIVES | NOVARTIS AG (CH) | 2009-10-14 | — | — | EP | disclosed |
| US-20080194551-A1 | Acetylene Derivatives | NOVARTIS PHARMA GMBH (AT) | 2008-08-14 | — | — | US | disclosed |
| EP-1877367-A1 | ACETYLENE DERIVATIVES | Novartis AG (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006114264-A1 | ACETYLENE DERIVATIVES | NOVARTIS AG (CH) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194551-A1 | Acetylene Derivatives | NAT1, B3GNT2, NAT10 | GRM5 3731/4885PIM1 1455/4885PIM2 1301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.