Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.82 |
| ▸ | BRD4 | O60885 | 14/20 | 0.82 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.77 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.77 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.77 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.77 |
| ▸ | EGFR | P00533 | 2/20 | 0.77 |
| ▸ | FES | P07332 | 2/20 | 0.77 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.77 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.77 |
| ▸ | CLK2 | P49760 | 2/20 | 0.77 |
| ▸ | NEK2 | P51955 | 2/20 | 0.77 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.77 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.77 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.77 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.77 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.77 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.77 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.77 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL383985 | 1.00 | PLK1 (0.82) | PLK1BRD4BRDTDAPK3PRKD3 | |
| SCHEMBL1066172 | 0.96 | PLK1 (0.75) | PLK1BRD4BRDTDAPK3PRKD3 | |
| SCHEMBL1066176 | 0.96 | PLK1 (0.75) | PLK1BRD4BRDTDAPK3PRKD3 | |
| SCHEMBL1064354 | 0.95 | PLK1 (0.74) | PLK1BRD4BRDTDAPK3PRKD3 | |
| SCHEMBL1064351 | 0.95 | PLK1 (0.74) | PLK1BRD4BRDTDAPK3PRKD3 | |
| SCHEMBL10313450 | 0.92 | PLK1 (0.69) | PLK1BRD4BRDTDAPK3PRKD3 | |
| SCHEMBL384074 | 0.90 | PLK1 (0.67) | PLK1BRD4BRDTDAPK3PRKD3 | |
| SCHEMBL1064778 | 0.90 | PLK1 (0.67) | PLK1BRD4BRDTDAPK3PRKD3 | |
| SCHEMBL28602063 | 0.90 | PLK1 (1.00) | PLK1BRD4BRDT | |
| SCHEMBL383778 | 0.90 | BRD4 (0.74) | PLK1BRD4BRDTDAPK3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140187774-A1 | METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2014-07-03 | — | — | US | disclosed |
| US-8637666-B2 | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-01-28 | — | — | US | disclosed |
| US-8524902-B2 | [1,2,4]triazolo[4,3-f]pteridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120277425-A1 | TETRAHYDROPTERIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-01 | — | — | US | disclosed |
| US-20120178926-A1 | METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-12 | — | — | US | disclosed |
| EP-2010542-B1 | 4,5-DIHYDRO-[1,2,4]TRIAZOLO[4,3-F]PTERIDINES AS PLK1 PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMA (US) | 2012-01-25 | — | — | EP | disclosed |
| US-8067417-B2 | Imidazo[1,2-F]pteridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-29 | — | — | US | disclosed |
| WO-2011038185-A2 | METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-31 | — | — | WO | disclosed |
| US-20110021519-A1 | TETRAHYDROPTERIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-27 | — | — | US | disclosed |
| US-7763629-B2 | Tetrahydropteridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-07-27 | — | — | US | disclosed |
| US-20090062292-A1 | Tetrahydropteridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277425-A1 | TETRAHYDROPTERIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | PRKCH, DMPK, MAP3K20 | PLK1 159/4885BRD4 1254/4885BRDT 1924/4885 |
| US-20090062292-A1 | Tetrahydropteridines useful as inhibitors of protein kinases | PRKCH, DMPK, MAP3K20 | PLK1 159/4885BRD4 1254/4885BRDT 1924/4885 |
| US-20140187774-A1 | METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | CDK20, CDK10, MAPK1 | PLK1 92/4885BRD4 2844/4885BRDT 1885/4885 |
| US-20120178926-A1 | METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | CDK20, CDK10, MAPK1 | PLK1 92/4885BRD4 2844/4885BRDT 1885/4885 |
| US-20110021519-A1 | TETRAHYDROPTERIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | PRKCH, DMPK, MAP3K20 | PLK1 159/4885BRD4 1254/4885BRDT 1924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.