Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 6/20 | 0.57 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839980 | 1.00 | CHRNA7 (0.57) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4198526 | 0.93 | CHRNA7 (0.64) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL1146293 | 0.86 | CHRNA7 (0.48) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL1146295 | 0.86 | CHRNA7 (0.48) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| Methane SCHEMBL17004325 | 0.85 | CHRNA7 (0.47) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL3181800 | 0.82 | CHRNA7 (0.65) | CHRNA7CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5421431 | 0.81 | CHRNA7 (0.65) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL3840206 | 0.81 | CHRNA7 (0.65) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL1459274 | 0.81 | CHRNA7 (0.65) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL1542514 | 0.81 | CHRNA7 (0.65) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236803-B2 | Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists | NOVARTIS AG (CH) | 2012-08-07 | — | — | US | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |