Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840839 | 1.00 | CHRM2 (0.46) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL3840297 | 0.84 | GAA (0.44) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL16656484 | 0.84 | CHRM2 (0.44) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL3839369 | 0.84 | CHRNA7 (0.49) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL3839374 | 0.84 | CHRNA7 (0.49) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL1542591 | 0.82 | CHRNA7 (0.47) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL3840340 | 0.81 | CNR2 (0.46) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL3840344 | 0.81 | CNR2 (0.46) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL3842988 | 0.81 | CHRNA7 (0.42) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL3844303 | 0.81 | CHRNA7 (0.48) | CHRM2CHRM1CHRM3CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| US-9012451-B2 | Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists | NOVARTIS AG (CH) | 2015-04-21 | — | — | US | disclosed |
| US-9012451-B2 | Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists | NOVARTIS AG (CH) | 2015-04-21 | — | — | US | disclosed |