Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840297 | 1.00 | GAA (0.44) | GAAATMCHRM2CHRM1CHRM3 | |
| SCHEMBL16642070 | 0.90 | TSHR (0.45) | GAAATMCHRM2CHRM1CHRM3 | |
| SCHEMBL3840344 | 0.90 | CNR2 (0.46) | GAAATMCHRM2CHRM1CHRM3 | |
| SCHEMBL3840340 | 0.90 | CNR2 (0.46) | GAAATMCHRM2CHRM1CHRM3 | |
| SCHEMBL3842109 | 0.86 | TSHR (0.45) | CHRM2CHRM1CHRM3CHRNA7LSS | |
| SCHEMBL3842111 | 0.86 | TSHR (0.45) | CHRM2CHRM1CHRM3CHRNA7LSS | |
| SCHEMBL3842055 | 0.86 | TSHR (0.45) | CHRM2CHRM1CHRM3CHRNA7LSS | |
| SCHEMBL3840329 | 0.86 | CHRNA7 (0.44) | GAAATMCHRM2CHRM1CHRM3 | |
| SCHEMBL3840335 | 0.86 | CHRNA7 (0.44) | GAAATMCHRM2CHRM1CHRM3 | |
| SCHEMBL16656484 | 0.85 | CHRM2 (0.44) | CHRM2CHRM1CHRM3CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |