Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840517 | 0.84 | CHRNA7 (0.54) | CHRNA7CNR2GAACHRM2CHRM4 | |
| SCHEMBL3840541 | 0.84 | CHRNA7 (0.54) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3840537 | 0.84 | CHRNA7 (0.54) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3840519 | 0.84 | CHRNA7 (0.54) | CHRNA7CNR2GAACHRM2CHRM4 | |
| SCHEMBL3844217 | 0.83 | CHRNA7 (0.55) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3846223 | 0.83 | CHRNA7 (0.55) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3181800 | 0.83 | CHRNA7 (0.65) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4198526 | 0.81 | CHRNA7 (0.64) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3839963 | 0.80 | CHRNA7 (0.62) | CHRNA7RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL3839959 | 0.80 | CHRNA7 (0.62) | CHRNA7RAB9ASMN1; SMN2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236803-B2 | Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists | NOVARTIS AG (CH) | 2012-08-07 | — | — | US | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |