Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.61 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840559 | 1.00 | CHRNA7 (0.61) | CHRNA7LSSGAAATMCHRM2 | |
| SCHEMBL3844247 | 0.87 | CHRNA7 (0.60) | CHRNA7LSSCHRM2CHRM4CHRM5 | |
| SCHEMBL3844243 | 0.87 | CHRNA7 (0.60) | CHRNA7LSSCHRM2CHRM4CHRM5 | |
| SCHEMBL3839996 | 0.86 | CHRNA7 (0.67) | CHRNA7LSSCHRM2CHRM4CHRM5 | |
| SCHEMBL3839999 | 0.86 | CHRNA7 (0.67) | CHRNA7LSSCHRM2CHRM4CHRM5 | |
| SCHEMBL3839404 | 0.84 | CHRNA7 (0.69) | CHRNA7LSSCHRM1 | |
| SCHEMBL3839400 | 0.84 | CHRNA7 (0.69) | CHRNA7LSSCHRM1 | |
| SCHEMBL3840601 | 0.84 | CHRNA7 (0.69) | CHRNA7LSSCHRM1 | |
| SCHEMBL3840606 | 0.84 | CHRNA7 (0.69) | CHRNA7LSSCHRM1 | |
| SCHEMBL1458612 | 0.83 | CHRNA7 (0.77) | CHRNA7LSSCHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| US-7579362-B2 | Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists | NOVARTIS AG (CH) | 2009-08-25 | — | — | US | claimed |