Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.64 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842282 | 1.00 | CHRNA7 (0.64) | CHRNA7LSSGLATSHRRXFP1 | |
| SCHEMBL3841488 | 0.89 | CHRNA7 (0.63) | CHRNA7LSSGLATSHRRXFP1 | |
| SCHEMBL3841492 | 0.89 | CHRNA7 (0.63) | CHRNA7LSSGLATSHRRXFP1 | |
| SCHEMBL3840208 | 0.89 | CHRNA7 (0.65) | CHRNA7LSSGLATSHRRXFP1 | |
| SCHEMBL3840206 | 0.89 | CHRNA7 (0.65) | CHRNA7LSSGLATSHRRXFP1 | |
| SCHEMBL3841313 | 0.86 | CHRNA7 (0.69) | CHRNA7LSSGLACHRM2CHRM1 | |
| SCHEMBL3841319 | 0.86 | CHRNA7 (0.69) | CHRNA7LSSGLACHRM2CHRM1 | |
| SCHEMBL3181800 | 0.85 | CHRNA7 (0.65) | CHRNA7LSSCHRM2CHRM1 | |
| SCHEMBL4198526 | 0.83 | CHRNA7 (0.64) | CHRNA7CHRM2CHRM1 | |
| SCHEMBL5400121 | 0.82 | CHRNA7 (0.60) | CHRNA7CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236803-B2 | Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists | NOVARTIS AG (CH) | 2012-08-07 | — | — | US | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |