Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840510 | 1.00 | CHRNA7 (0.75) | CHRNA7ALDH1A1KDM1ACHRNB2CHRNA4 | |
| Aqw051 SCHEMBL1459285 | 0.86 | CHRNA7 (1.00) | CHRNA7LSS | |
| Aqw051 SCHEMBL1459287 | 0.86 | CHRNA7 (1.00) | CHRNA7LSS | |
| Aqw051 SCHEMBL29604108 | 0.86 | CHRNA7 (1.00) | CHRNA7LSS | |
| Aqw051 SCHEMBL29463332 | 0.86 | CHRNA7 (1.00) | CHRNA7LSS | |
| SCHEMBL1458612 | 0.86 | CHRNA7 (0.77) | CHRNA7LSS | |
| SCHEMBL1458614 | 0.86 | CHRNA7 (0.77) | CHRNA7LSS | |
| SCHEMBL1459239 | 0.85 | CHRNA7 (0.77) | CHRNA7LSS | |
| SCHEMBL1459240 | 0.85 | CHRNA7 (0.77) | CHRNA7LSS | |
| SCHEMBL3841703 | 0.84 | CHRNA7 (0.61) | CHRNA7KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| US-7579362-B2 | Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists | NOVARTIS AG (CH) | 2009-08-25 | — | — | US | claimed |