Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.79 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.71 |
| ▸ | PRKCG | P05129 | 3/20 | 0.71 |
| ▸ | PRKCB | P05771 | 3/20 | 0.71 |
| ▸ | PRKCA | P17252 | 3/20 | 0.71 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.71 |
| ▸ | PRKCH | P24723 | 3/20 | 0.71 |
| ▸ | CDK2 | P24941 | 3/20 | 0.71 |
| ▸ | PRKCI | P41743 | 3/20 | 0.71 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.71 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.71 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.71 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.71 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.71 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14795987 | 1.00 | CHEK1 (0.79) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL14796445 | 0.90 | CHEK1 (0.77) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3841380 | 0.90 | CHEK1 (0.77) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL14796349 | 0.90 | CHEK1 (0.77) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3737545 | 0.89 | CHEK1 (0.82) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL14795559 | 0.89 | CHEK1 (0.82) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3383628 | 0.89 | CHEK1 (0.82) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3384695 | 0.88 | CHEK1 (1.00) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3383518 | 0.88 | CHEK1 (1.00) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL31207550 | 0.88 | CHEK1 (1.00) | CHEK1PRKD3PRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313734-B1 | AZA HETEROCYCLIC DERIVATIVES AND THEIR THERAPEUTIC USE | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-11 | — | — | EP | disclosed |
| US-7368459-B2 | Heterocyclic compounds | CHIRON CORPORATION (US) | 2008-05-06 | — | — | US | disclosed |
| US-20070032528-A1 | Heterocyclic compounds | RENHOWE PAUL A | 2007-02-08 | — | — | US | disclosed |
| US-7138409-B2 | Heterocyclic compounds | CHIRON CORPORATION (US) | 2006-11-21 | — | — | US | disclosed |
| US-20050137188-A1 | Heterocyclic compounds | CHIRON CORPORATION | 2005-06-23 | — | — | US | disclosed |
| US-6759417-B2 | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITORS; SUCH AS 7-AMINO-6-(1H-BENZIMIDAZOL-2-YL)-3,4-DIHYDRO-5H-IMIDAZO(4,5-B)PYRIDIN-5-ONE | CHIRON CORPORATION | 2004-07-06 | — | — | US | disclosed |
| US-6756383-B2 | SUCH AS 3-(2-(METHOXYCARBONYL)ACETYLAMINO)PYRIDINE-4-CARBOXYLIC ACID FOR TREATMENT OF DISEASES CHARACTERIZED BY ACTIVITY OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASES; ENZYME INHIBITORS | CHIRON CORPORATION | 2004-06-29 | — | — | US | disclosed |
| US-20040002518-A1 | Heterocyclic compounds | CHIRON CORPORATION | 2004-01-01 | — | — | US | disclosed |
| EP-1313734-A2 | AZA HETEROCYCLIC DERIVATIVES AND THEIR THERAPEUTIC USE | CHIRON CORPORATION (US) | 2003-05-28 | — | — | EP | disclosed |
| US-20020103230-A1 | Heterocyclic compounds | CHIRON CORPORATION | 2002-08-01 | — | — | US | disclosed |
| WO-2002018383-A2 | AZA HETEROCYCLIC DERIVATIVES AND THEIR THERAPEUTIC USE | CHIRON CORPORATION (US) | 2002-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103230-A1 | Heterocyclic compounds | SLCO2A1, SLCO1B1, SLCO2B1 | CHEK1 4225/4885PRKD3 3266/4885PRKCG 4351/4885 |
| US-20070032528-A1 | Heterocyclic compounds | SLCO4C1, SLCO2B1, SLCO1B1 | CHEK1 3861/4885PRKD3 3186/4885PRKCG 4196/4885 |
| US-20050137188-A1 | Heterocyclic compounds | SLCO4C1, SLCO2B1, SLCO1B1 | CHEK1 3861/4885PRKD3 3186/4885PRKCG 4196/4885 |
| US-20040002518-A1 | Heterocyclic compounds | SLCO2A1, SLCO1B1, SLCO2B1 | CHEK1 4225/4885PRKD3 3266/4885PRKCG 4351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.