Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 1.00 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 1.00 |
| ▸ | DPP7 | Q9UHL4 | 9/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | FAP | Q12884 | 1/20 | 0.70 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.70 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842850 | 1.00 | DPP4 (1.00) | DPP4DPP8DPP7KCNH2FAP | |
| SCHEMBL3842848 | 1.00 | DPP4 (1.00) | DPP4DPP8DPP7KCNH2FAP | |
| SCHEMBL3840953 | 0.93 | DPP4 (1.00) | DPP4DPP8DPP7KCNH2FAP | |
| SCHEMBL3842509 | 0.90 | DPP4 (1.00) | DPP4DPP8DPP7KCNH2FAP | |
| SCHEMBL3843211 | 0.90 | DPP4 (1.00) | DPP4DPP8DPP7KCNH2FAP | |
| SCHEMBL3842844 | 0.89 | DPP4 (1.00) | DPP4DPP8DPP7KCNH2FAP | |
| SCHEMBL3840882 | 0.89 | DPP4 (1.00) | DPP4DPP8DPP7KCNH2FAP | |
| SCHEMBL3840885 | 0.89 | DPP4 (1.00) | DPP4DPP8DPP7KCNH2FAP | |
| SCHEMBL3844733 | 0.87 | DPP4 (0.76) | DPP4DPP8DPP7KCNH2FAP | |
| SCHEMBL3844730 | 0.87 | DPP4 (0.76) | DPP4DPP8DPP7KCNH2FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116541-B1 | Proline derivatives and their use as dipeptidyl peptidase IV inhibitors | PFIZER PROD INC (US) | 2015-02-25 | — | — | EP | disclosed |
| EP-2116541-A1 | Proline derivatives and their use as dipeptidyl peptidase IV inhibitors | Pfizer Products Incorporated (US) | 2009-11-11 | — | — | EP | disclosed |