Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843584 | 1.00 | CHRNA7 (0.51) | CHRNA7ALDH1A1HTR3ACYP1A2CYP2D6 | |
| SCHEMBL16642063 | 0.91 | CHRNA7 (0.44) | CHRNA7ALDH1A1HTR3ACHRM1CHRM2 | |
| SCHEMBL3844172 | 0.86 | CHRNA7 (0.48) | CHRNA7CHRM1CHRM2CHRM3 | |
| SCHEMBL3844170 | 0.86 | CHRNA7 (0.48) | CHRNA7CHRM1CHRM2CHRM3 | |
| SCHEMBL999385 | 0.86 | CHRNA7 (0.64) | CHRNA7ALDH1A1CYP1A2CYP2D6CHRM1 | |
| SCHEMBL999386 | 0.86 | CHRNA7 (0.64) | CHRNA7ALDH1A1CYP1A2CYP2D6CHRM1 | |
| SCHEMBL1459611 | 0.85 | CHRNA7 (0.51) | CHRNA7CHRM1CHRM2CHRM3 | |
| SCHEMBL5397013 | 0.85 | MAP4K4 (0.47) | CHRNA7CHRM1CHRM2CHRM3 | |
| SCHEMBL3840502 | 0.85 | TSHR (0.49) | CHRNA7CHRM1CHRM2CHRM3 | |
| SCHEMBL5394680 | 0.85 | MAP4K4 (0.47) | CHRNA7CHRM1CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| US-9012451-B2 | Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists | NOVARTIS AG (CH) | 2015-04-21 | — | — | US | disclosed |
| US-9012451-B2 | Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists | NOVARTIS AG (CH) | 2015-04-21 | — | — | US | disclosed |