Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2951311 | 0.99 | HRH3 (0.57) | HRH3MEN1KMT2AHRH4ROCK2 | |
| SCHEMBL3853140 | 0.94 | HRH3 (0.59) | HRH3MEN1KMT2AHRH4ROCK2 | |
| Hydrochloric Acid SCHEMBL2950926 | 0.93 | HRH3 (0.58) | HRH3MEN1KMT2AHRH4ROCK2 | |
| SCHEMBL2951314 | 0.85 | HRH3 (0.64) | HRH3MEN1KMT2AROCK2CYP3A4 | |
| SCHEMBL2951713 | 0.80 | HRH3 (0.58) | HRH3MEN1KMT2A | |
| SCHEMBL3848464 | 0.79 | HRH3 (0.70) | HRH3MEN1KMT2AHRH4SYK | |
| SCHEMBL3843748 | 0.79 | HRH3 (0.89) | HRH3MEN1KMT2ASYK | |
| SCHEMBL2950114 | 0.79 | HRH3 (0.73) | HRH3MEN1KMT2AROCK2CYP3A4 | |
| Hydrochloric Acid SCHEMBL2946801 | 0.79 | HRH3 (0.69) | HRH3MEN1KMT2AHRH4SYK | |
| Hydrochloric Acid SCHEMBL2951266 | 0.79 | HRH3 (0.88) | HRH3MEN1KMT2ASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841734-B1 | 5-AMINOINDOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-29 | — | — | EP | claimed |
| EP-1841734-A2 | 5-AMINOINDOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-10 | — | — | EP | claimed |
| WO-2006077024-A2 | 5-AMINOINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-27 | — | — | WO | claimed |
| EP-1841734-A2 | 5-AMINOINDOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006077024-A2 | 5-AMINOINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-27 | — | — | WO | disclosed |