Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13674671 | 0.91 | SMN1; SMN2 (0.47) | RAB9ASMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL3825251 | 0.91 | RXFP1 (0.46) | RAB9ASMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL3831608 | 0.90 | IKBKB (0.50) | RAB9ASMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL13675586 | 0.85 | MAPT (0.46) | RAB9ASMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL3842362 | 0.80 | GAA (0.47) | RAB9ASMN1; SMN2MAPTNPC1RXFP1 | |
| SCHEMBL13675833 | 0.80 | MAPT (0.42) | RAB9ASMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL4557806 | 0.78 | MEN1 (0.48) | RAB9ASMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL4559238 | 0.73 | BTK (0.50) | RAB9ASMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL3827482 | 0.71 | CYP1A2 (0.54) | RAB9AMAPTP2RY1MAPK8MAPK10 | |
| SCHEMBL22864101 | 0.68 | MAPK14 (0.56) | MAPTCRHR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718297-A4 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-09-02 | — | — | EP | disclosed |
| EP-1718297-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005070042-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-04 | — | — | WO | disclosed |