Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.47 |
| ▸ | SCN7A | Q01118 | 3/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | CCR9 | P51686 | 2/20 | 0.36 |
| ▸ | BRD1 | O95696 | 3/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.33 |
| ▸ | BRPF3 | Q9ULD4 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839527 | 0.83 | KCNH2 (0.40) | KCNH2 | |
| SCHEMBL3846427 | 0.83 | HDAC1 (0.36) | KCNH2 | |
| SCHEMBL4779522 | 0.78 | SCN7A (0.58) | KCNH2SCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL27759451 | 0.74 | KCNH2 (0.47) | KCNH2SCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL706182 | 0.72 | KCNH2 (0.55) | KCNH2SCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL3842134 | 0.70 | — | — | |
| SCHEMBL19212781 | 0.70 | KCNH2 (0.45) | KCNH2SCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL19211607 | 0.69 | KCNH2 (0.43) | KCNH2SCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL708277 | 0.68 | KCNH2 (0.59) | KCNH2SCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL4789884 | 0.68 | KCNH2 (0.66) | KCNH2SCN7ASCN5ASCN2ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044077-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | Glaxo Group Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009700-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |