Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3844303 | 0.87 | CHRNA7 (0.48) | CHRNA7CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL999496 | 0.87 | CHRNA7 (0.48) | CHRNA7CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL999498 | 0.87 | CHRNA7 (0.48) | CHRNA7CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5402635 | 0.86 | CHRNA7 (0.48) | CHRNA7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5417567 | 0.86 | CHRNA7 (0.48) | CHRNA7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3839960 | 0.86 | CHRNA7 (0.43) | LSSCHRNA7GLATSHRRXFP1 | |
| SCHEMBL999385 | 0.86 | CHRNA7 (0.64) | CHRNA7CHRM2CHRM1NTMT1CHRM4 | |
| SCHEMBL999386 | 0.86 | CHRNA7 (0.64) | CHRNA7CHRM2CHRM1NTMT1CHRM4 | |
| SCHEMBL3839954 | 0.86 | CHRM2 (0.47) | LSSCHRNA7GAATSHRRXFP1 | |
| SCHEMBL3840502 | 0.86 | TSHR (0.49) | LSSCHRNA7GLANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| US-9012451-B2 | Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists | NOVARTIS AG (CH) | 2015-04-21 | — | — | US | disclosed |
| US-9012451-B2 | Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists | NOVARTIS AG (CH) | 2015-04-21 | — | — | US | disclosed |